African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2284

Full Length Research Paper

Synthesis and antifungal activity of new 1-(2,4-dichloro phenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2-en-1-one derivatives

Yinwei Ruan, Linhong Jin, Jiang He, Song Yang, Pinaki S. Bhadury, Ming He, Zhenchao Wang and Baoan Song*    
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China.    
Email: [email protected], [email protected]

  •  Accepted: 31 March 2011
  •  Published: 31 May 2011

Abstract

A series of novel 1-(2,4-dichlorophenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2- en-1-one derivatives were synthesized in good yields by an aldol condensation between 1-(2,4-dichlorophenyl)-2-(1H-1,2, 4-triazol-1-yl) ethanone and an aryl aldehyde. The structures were established through 1H NMR and 13C NMR spectroscopy and elemental analysis. All compounds 4a-l at a concentration of 50 mg/L showed inhibition against the growth of Gibberella zeae, Fusarium oxysporium, Cytospora mandshurica. The title compound 4a displayed high antifungal activities against G. zeae, F. oxysporium, C. mandshurica comparable to hymexazol.

 

Key words: 1H-1,2,4-triazol derivative, prop-2-en-1-one moiety, antifungal activity.

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