Abstract

The effects of aqueous extract of Triplochiton scleroxylon (TS) on platelet and associated parameters, namely, platelet counts, volume and distribution width in alloxan-induced diabetic rabbits (New Zealand strain) were carried out. Plasma glucose concentration was also monitored as the test rabbits were treated with at least 100 ml of the aqueous extract daily through clean drinking troughs for a period of 28 days. Haematological swelab auto counter 920E⁺ (UK) was used in blood analysis. Analysis of results showed that extract of TS did not have any significant effects (P>0.05) on the platelet counts, volume and distribution width. However, plasma glucose concentration decreased (P<0.05) on the 18, 24 and 28th days following treatment with aqueous extract of Triplochiton scleroxylon. The use of this extract in the treatment of diabetes mellitus in some part of Nigeria is not likely to accentuate any of the abnormalities or diseases/disorders of the platelets.

Key words: Anti–diabetic, Triplochiton scleroxylon, platelets, alloxan–induced diabetic rabbits.