Biotechnology and Molecular Biology Reviews

  • Abbreviation: Biotechnol. Mol. Biol. Rev.
  • Language: English
  • ISSN: 1538-2273
  • DOI: 10.5897/BMBR
  • Start Year: 2006
  • Published Articles: 102


External, extrinsic and intrinsic noise in cellular systems: analogies and implications for protein synthesis

Pratap R. Patnaik
Institute of Microbial Technology Sector 39-A, Chandigarh-160036, India. IMTECH Communication no.034/2006
Email: [email protected]

  •  Accepted: 20 November 2006
  •  Published: 31 December 2006


Multicellular systems, typically in bioreactors with one or more feed streams, are under the influences of intrinsic (intra-cellular), extrinsic (inter-cellular) and external (environmental) noise. Of these, intrinsic noise is relatively less important in determining protein synthesis and reactor behavior. Although extrinsic noise and external noise have different origins and controls, they have similarities and interactions. The interactions make it important to control both kinds of noise optimally to enhance the gene expression of a desired protein, and the similarities enable this to be done. These aspects are discussed to evolve a comprehensive noise filtering and control strategy for large bioreactors operated in realistic (noisy) environments.


Key words: cellular noise sources, analogies, interactions, protein synthesis.