Biotechnology and Molecular Biology Reviews

  • Abbreviation: Biotechnol. Mol. Biol. Rev.
  • Language: English
  • ISSN: 1538-2273
  • DOI: 10.5897/BMBR
  • Start Year: 2006
  • Published Articles: 102


Mechanistic links between maternal bacterial infection and cerebral palsy

Heping Zhou
Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, New Jersey 07079, USA.
Email: [email protected]

  •  Accepted: 05 March 2008
  •  Published: 30 April 2008


Maternal bacterial infection is known as a causal factor for preterm labor and neonatal morbidity. In recent years, both epidemiological and experimental studies have identified maternal bacterial infection as one of the causal factors for the development of cerebral palsy (CP) in the offspring. This review examines accumulating evidence that as critical mediators of the host’s response to fighting the infecting bacteria, inflammatory cytokines and oxidative stress also play important roles in maternal bacterial infection-induced white matter damage and ultimately the development of CP in the offspring. Understanding the actions of cytokines and oxidative stress in CP development could potentially lead to novel and effective therapeutic strategies. 
Key words: maternal infection; cerebral palsy; lipopolysaccharide; cytokine; oxidative stress