Langerhans cell histiocytosis (LCH) is defined as a clonal proliferation of Langerhans phenotypic-like cells. Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. We report an interesting, previously misdiagnosed and relapsing case of adult skin limited to LCH in a 25 years old female patient presented with well defined erythematous, dry scaly plaques in the face, trunk and extremities for 10 years duration, and then remains stable over the time. The case is diagnosed and confirmed histopathologically, considered to be the second case of LCH and first case as adult Letterer Siwe been reported in Sudan.
Key words: Immunology, Langerhans cell histiocytosis, lymphoid, Helicobacter pylori.
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