June 2011

In vitro- and in vivo- experimental models for balanced activity of oncogenes and tumor-suppressor genes in normal and malignant cells

Gene transfer in laboratory-cultivated mouse embryonic stem cells (mESCs) was made by appropriate recombinant DNA-constructs. Electrophorhetic profiles of genetic material from wild type (WT) on oncogene Dcn1 and “knock-down” (KD) on it inbred lines of experimental mice differed not only on it, but also on the tumor-suppressor gene HACE1 between both categories of laboratory...

Author(s): Iskra Ventseslavova Sainova, Ilina Vavrek, Velichka Pavlova, Ivan Iliev, Lilija Yossifova, Elena Gardeva, Elena Nikolova, Teodora Daneva, Roberto Nitsch and Anna Nitsch

June 2011

Langerhans cell histiocytosis (LCH) associated with Helicobacter pylori infection

Langerhans cell histiocytosis (LCH) is defined as a clonal proliferation of Langerhans phenotypic-like cells. Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. We report an interesting, previously misdiagnosed and relapsing case of adult skin limited to LCH in a 25 years old female patient presented with well defined erythematous, dry scaly plaques...

Author(s): Bashir A. H. H, Lamyaa A. M and Al Hassan A. M