International Journal of
Biotechnology and Molecular Biology Research

  • Abbreviation: Int. J. Biotechnol. Mol. Biol. Res.
  • Language: English
  • ISSN: 2141-2154
  • DOI: 10.5897/IJBMBR
  • Start Year: 2010
  • Published Articles: 100

Full Length Research Paper

HLA-DQA1 and –DQB1 genotyping in individuals with family history of gastritis

Nibras S. Al-Ammar1, Ihsan Al-Saimary1*, Saad Sh. Hamadi2 and Ma Luo2
1Department of Microbiolody, College of Medicine, University of Basrah, Basrah, Iraq. 2Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq.
Email: [email protected]

  •  Accepted: 15 April 2011
  •  Published: 30 June 2011

Abstract

The objective was to study HLA-DQA1 and HLA-DQB1 genotyping in individuals (patients and controls) with family history of gastritis. This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was done in College of Medicine, University of Manitoba, and Winnpeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 100 patients (41 males and 59 females) and a total of 30 controls (18 males and 12 females) were included in this study. A significant decreased frequency of DQA1*0201 allele was found in individuals (patients + controls) with family history of gastritis with a strong association (odds ratio = 4.57), as compared with individuals without family history of gastritis. Significant increased alleles frequencies of DQA1*0402 and DQB1*0402 were found in individuals with family history of gastritis, but with weak association (odds ratios, 0.16 and 0.20 respectively), as compared with individuals without family history of gastritis.

Key words: HLA-DQA1, HLA-DQB1, genotyping and gastritis.