International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 112

Full Length Research Paper

Acute myeloid leukaemia associated to chromosome 6: Clinical and phenotypical implications in two pediatric patients with chromosome trisomy and translocation

  Aparicio-Rodríguez J. M.1,6*, Hurtado-Hernández M. L.2, Marroquín-García I.2, Rojas-Rivera G. A.2, Cuellar-López F.3, Cubillo-León M. A.4, Garrido-Hernández M. A.5and Chatelain-Mercado S.7
  1Department of Genetics, Hospital para el Niño Poblano, Puebla, Mexico. 2Department of Cytogenetics, Hospital para el Niño Poblano, Puebla, Mexico. 3Department of Urology, Hospital para el Niño Poblano, Puebla, Mexico. 4Department of Physical Therapy, Hospital para el Niño Poblano, Puebla, Mexico. 5Department of Oncohematology, Hospital para el Niño Poblano, Puebla, Mexico. 6Department of Estomatology, Benemérita Universidad Autónoma de Puebla, México. 7Department of Biotechnology, Universidad Autónoma Metropolitana, Mexico City, Mexico
Email: [email protected]

  •  Accepted: 11 May 2012
  •  Published: 30 November 2012

Abstract

 

Chromosome aberrations are considered alterations in the chromosome number or structure. They are mainly considered due to gametogenesis inborn error or during the zygote first cellular divisions. Among 4617 chromosomal studies performed during 19 years (from 1992 to 2011), at Hospital Para El Niño Poblano in México, 34.6% (1596 patients) had chromosomal alterations. Among these study populations, a male and a female pediatric patient were described, with 6;9 translocation and trisomy of chromosome 6, where chromosome changes are classified as structural or numeric alterations respectively, and a number of leukemias has been associated with specific chromosomal translocations. Both cases were described in this study analyzing their hematological, clinical features, medical treatments and prognosis.

 

Key words: Chromosome, karyotype, leukemia, numeric and structural chromosome changesa

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