International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 131

Full Length Research Paper

Corticosteroid binding globulin and glucocorticoid receptor genotypes influence body composition in a male population

Elodie Richard1, José-Manuel Fernandez-Real 2, Abel Lopez-Bermejo2, Wifredo Ricart2, Henri Déchaud3, Michel Pugeat3 and Marie-Pierre Moisan1*
  1Laboratoire PsyNuGen, INRA,  UMR 1286, CNRS 5226, Université de Bordeaux, 146 rue Léo Saignat, F-33077 Bordeaux, France. 2Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, “Dr. Josep Trueta” and CIBER Fisiopatología de la Obesidad y Nutrición CB06/03/010, 17007 Girona, Spain. 3Fédération d’Endocrinologie, INSERM U863, IFR62, Groupe Hospitalier Est F-69437 Lyon, France.
Email: [email protected]

  •  Accepted: 04 June 2009
  •  Published: 31 July 2009

Abstract

 

Glucocorticoid Receptor (GR) polymorphisms have been repeatedly associated with obesity and metabolic parameters in man. We have previously shown the genetic influence of a polymorphism in the gene encoding CBG on some obesity parameters in a small female population. In this study we have explored possible genetic associations between obesity and metabolic measures and CBG or GR polymorphisms in a new male population. Two hundred and ninety-five men with body mass index (BMI) ranging from 19 to 55 kg/m2 were studied. Serum CBG levels, CBG and GR gene polymorphisms in relation with anthropometric and biochemical parameters were analysed. GR BclI polymorphism was found to influence weight, BMI, waist circumference and glucose levels. CBG polymorphism showed a significant effect for BMI and waist circumference. The frequency of CBG allele 90 was markedly increased among men with morbid obesity compared to the rest of the population (30 versus 18%, p=0.02). The influence of GR BclI polymorphism is replicated in an additional population and CBG polymorphism has a small but significant influence on obesity in men. Further studies are needed to understand the mechanism by which these polymorphisms impact on cortisol and obesity.

 

Key words: Obesity, genetics, cortisol, transcortin, glucocorticoids.