International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 137

Full Length Research Paper

Heliclobacter pylori associated chronic gastritis: Endoscopic and pathological findings, comparative study

Awwad K. A. Alenezy
  • Awwad K. A. Alenezy
  • Department of Family and Community Medicine, Northern Borders University (KSA), Arar Saudi Arabia
  • Google Scholar
Taha M. M. Hassan*
  • Taha M. M. Hassan*
  • Department of Pathology, College of Medicine, Bani Sweif University, Egypt
  • Google Scholar

  •  Received: 13 February 2014
  •  Accepted: 03 March 2014
  •  Published: 30 March 2014


Helicobacter pylori have been established as a major etiologic factor in the pathogenesis of chronic gastritis, peptic ulcer disease and in the development of gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. This study was conducted on 100 patients. All underwent upper endoscopy, and antral and corpus, and duodenal biopsies were taken. Findings of endoscopic gastritis were observed in 83 patients (p Ë‚0.001). Histologically mononuclear inflammatory cellular infiltrates were seen in 95 cases, majority of them showed grade 1 gastritis (64), whereas grade 2 and grade 3 gastritis found in 16 and 15 biopsies. The relationship between endoscopic and histological findings was significant (p Ë‚0.001). H. pylori colonization was found in the majority of the biopsies (92) (p Ë‚0.001). This study concluded that accurate endoscopic and histopathological examination of gastritis according to the Sydney grading system is valuable indicator of H. pylori infection. Endoscopical abnormalities suggesting gastritis were significantly correlated with the histopathologic findings. Finally, chronic active gastritis with lymphoid follicles was significantly correlated with H. pylori infection (p Ë‚0.001).


Key words: Chronic gastritis, Helicobacter pylori, endoscopic and histological grading.