International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Frequency of hepatitis B and hepatitis C infections and its association with development of factor VIII inhibitor in hemophiliacs in Hamadan Province of Iran

Amir Houshang Mohammad Alizadeh
  • Amir Houshang Mohammad Alizadeh
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Mehdi Rezazadeh
  • Mehdi Rezazadeh
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Mitra Ranjbar
  • Mitra Ranjbar
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Kianoush Donboli
  • Kianoush Donboli
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Farahnaz Fallahian
  • Farahnaz Fallahian
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Mehrdad Hadjilooi
  • Mehrdad Hadjilooi
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Seyed Mohsen Mousavi
  • Seyed Mohsen Mousavi
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Mohammad Abbasi
  • Mohammad Abbasi
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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Seyed Moayed Alavian
  • Seyed Moayed Alavian
  • Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Tehran, School of Medical Science, 7th floor, Taleghani Hospital, Parvaneh Ave., Tabnak Str., Evin, Tehran, Iran-19857, P. O. Box: 19835-178.
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  •  Accepted: 07 May 2009
  •  Published: 30 May 2009

Abstract

The aim of the present study was to determine the frequency of hepatitis B and C infections; to analyze the markers of inflammation and liver function tests; and to assess the possible association between factor VIII inhibitor and hepatitis C and/or hepatitis B infections in hemophiliacs of Hamadan province of Iran. Subjects with confirmed diagnosis of hemophilia who agreed to participate were recruited in this case-series study. Hepatitis B and C serology, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and factor VIII levels, and factor VIII inhibitor titer were analyzed. Frequency of anti hepatitis C antibody and hepatitis B surface antigen were 59.1 and 5%, respectively. Factor VIII inhibitor was present in 47.8% of hemophilia A group, and its presence was neither associated with hepatitis B and hepatitis C infections nor with AST, ALT levels. Student’s t-test showed a significant statistical association between duration of hemophilia and development of factor VIII inhibitor (p value =0.038). Frequency of hepatitis B and C infections in hemophiliacs is significant. There was a significant association between duration of hemophilia and hepatitis C infection (p value <0.011). One suggestion is that current blood product screening methods for eliminating blood-borne viruses might not be effective enough. Further investigation is recommended.

Key words: Hepatitis B, hepatitis C, hemophilia, Iran.

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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