Full Length Research Paper
Abstract
This study was conducted to evaluate the protective effects of organic and sulfur treated apricot on the azoxymethane-induced carcinogenesis by antioxidant markers and telomerase activity. Spraque Dawley rats (n = 35) were fed with two kinds of dried apricots (sun-dried or sulfur fumigated), with or without azoxhymethane (AOM). Rats were sacrificed after seven weeks for measurement of reduced glutathione, malondialdehyde, nitric oxide levels and telomerase activity. The results demonstrated that, oxidative stress and telomerase activity were increased in AOM induced group; decreased in apricot fed group (p < 0.001). With respect to the antioxidant activity; sulfur fumigated apricot group could be more effective than the sun-dried apricot (p < 0.005). On the contrary, telomerase activity was found to be higher in AOM induced sulfur fumigated apricot group compared to that of the group with AOM and organic apricot. These results demonstrate that sulfur fumigated apricot or sun dried apricot + azoxhymethane groups had higher antioxidant activity compared to azoxhymethane group. Sun-dried apricot decreaseD the telomerase activity more than sulphur fumigated apricot in azoxyhmethane administirated rats. Apricot treatment also decreased oxidative damage. Taken together, reduction in both telomerase activity and oxidative stress might indicate the benefical effects of apricot suplements against the damages caused by azoxhymethane in rats.
Key words: Apricot, azoxhymethane, glutathione, malondialdehyde, nitric oxide, telomerase.
Abbreviation
AOM, Azoxhymethane; GSH, glutathione; MDA, malondialdehyde; NO, nitric oxide; ip, intraperitoneal; s.c, subcutaneous; AOM+SDA, azoxhymethane+sun dried apricot; AOM+SFA, azoxhymethane+sulfur fumigated apricots; SDA, sun dried apricot; SFA, sulfur fumigated apricot; TRAP, telomeric repeat amplification protocol; SPSS, statistical package for social sciences; ROS, reactive oxygen species; SO2, sulphur dioxide; GSSG, glutathione disulfide; ACF, aberrant crypt foci.
Copyright © 2024 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0