International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 128

Full Length Research Paper

Protective effect of the combination of exercise and curcumin supplementation on cardiac system in rats exposed to lead

Valiollah Dabidi Roshan
  • Valiollah Dabidi Roshan
  • Department of Sport Physiology, College of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran.
  • Search for this author on:
  • Google Scholar
Mina Rahimi
  • Mina Rahimi
  • Exercise Physiology, Azad University of Sari, Sari, Mazandaran, Iran.
  • Search for this author on:
  • Google Scholar
Vahid Shirinbayan
  • Vahid Shirinbayan
  • Department of Sport Physiology, College of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran.
  • Search for this author on:
  • Google Scholar
Soleiman Mahjoub
  • Soleiman Mahjoub
  • Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
  • Search for this author on:
  • Google Scholar
Mahdi Hosseinzadeh
  • Mahdi Hosseinzadeh
  • Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers vej 7D-3, DK 9220 Aalborg, Denmark.
  • Search for this author on:
  • Google Scholar


  •  Accepted: 22 May 2012
  •  Published: 31 August 2012

Abstract

Effects of exercise training and curcumin supplementation, alone or combined on cardioprotective markers in left ventricle were investigated in rats during chronic exposure to lead acetate. Forty (40) male rats were randomly assigned to; sham (Sh), training + lead (TL), curcumin + lead (CL), training + curcumin + lead (TCL), and lead (L) groups. Heat shock protein (HSP72) and enzyme activities were determined in rat hearts after receiving 20 mg/kg of lead acetate in the TL, TCL, CL and L groups and 30 mg/kg turmeric in the TCL and CL groups for 8 weeks, 3 times a week. In addition, the rats in the TL and TCL groups performed treadmill running at a speed of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. One-way analysis of variance (ANOVA) indicated that administration of lead can evoke a significant increase in HSP72 and malondialdehyde (MDA) in the left ventricle homogenates and a significant decrease in serum total antioxidant capacity (TAC). However, endurance training and\or curcumin supplementation resulted in a significant decrease in HSP72 and MDA levels and significant increase in the level of serum TAC (serum Total Antioxidant Capacity). These results can suggest that concomitant exercise and curcumin supplementation may have a more cardioprotective effect observed by amelioration of lead-induced cardiotoxicity.

 

Key words: Turmeric, endurance training, lead acetate, stress proteins, antioxidant.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 4 No. 8
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES