International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 124

Full Length Research Paper

Liver function tests in type 2 Sudanese diabetic patients

Ayman S. Idris
  • Ayman S. Idris
  • Department of Biochemistry, Faculty of Science and Technology, Al-Neelain University, P. O. Box 12702, Al Baladya St. Khartoum, Sudan.
  • Google Scholar
Koua Faisal Hammad Mekky
  • Koua Faisal Hammad Mekky
  • Department of Biochemistry, Faculty of Science and Technology, Al-Neelain University, P. O. Box 12702, Al Baladya St. Khartoum, Sudan.
  • Google Scholar
Badr Eldin Elsonni Abdalla
  • Badr Eldin Elsonni Abdalla
  • Department of Biochemistry, Faculty of Medicine, University of Gezira, Sudan.
  • Google Scholar
Khalid Altom Ali
  • Khalid Altom Ali
  • Department of Biochemistry, Faculty of Medicine, International University of Africa, Sudan.
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  •  Accepted: 21 January 2011
  •  Published: 28 February 2011

Abstract

This study was planned to evaluate the liver function in patients with type 2 diabetes mellitus by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), total protein and albumin. The study was carried out in Wad Medani, Abo Agla Diabetes Centre. 50 patients with type 2 diabetes mellitus (23 male and 27 female) were included in the study. Their ages ranged between 43 and 79 years. Thirty matched normal individuals were taken as control group. In the present study, mean values of ALT, AST and GGT were significantly higher in patients than in the control (P<0.001). Total protein and albumin concentrations in patients were lower compared to control group (P<0.01). The mean of serum glucose in patients revealed significant difference (P<0.000) in comparison to the control group. Although the differences were statistically significant, the means of ALT, AST, GGT, total protein and albumin were falling within the normal range. Overall 11 patients (22%) had at least one or more abnormal liver function test enzymes.

 

Key words: Type 2 diabetes mellitus, hyperinsulinemia, liver function, metabolism, metabolic disorders, Sudanese.