International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 127

Full Length Research Paper

A positive role for selenium in mitigating complications associated with fructose-induced metabolic syndrome in rats

Kholoud S. Ramadan
  • Kholoud S. Ramadan
  • Biochemistry Department, King Abdulaziz University, Sciences Faculty for Girl's, P. O. Box 51459, Jeddah- 21453, Saudi Arabia. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
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Jehad M. Yousef
  • Jehad M. Yousef
  • Biochemistry Department, King Abdulaziz University, Sciences Faculty for Girl's, P. O. Box 51459, Jeddah- 21453, Saudi Arabia.
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Amal H. Hamza
  • Amal H. Hamza
  • Biochemistry Department, King Abdulaziz University, Sciences Faculty for Girl's, P. O. Box 51459, Jeddah- 21453, Saudi Arabia.Biochemistry and Nutrition Department, Faculty of Women, Ain Shams University, Cairo, Egypt.
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Safinaz E. Abdel Basset
  • Safinaz E. Abdel Basset
  • Biochemistry Department, King Abdulaziz University, Sciences Faculty for Girl's, P. O. Box 51459, Jeddah- 21453, Saudi Arabia. Medical Biochemistry Department, National Research Center, Cairo, Egypt.
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  •  Accepted: 19 November 2012
  •  Published: 31 December 2012

Abstract

This study was designed to investigate the potential role of selenium on metabolic syndrome induced by fructose in rats. Thirty male Wister Albino rats weighing 185 to 225 g were used. The rats were randomly divided into 3 groups, 10 rats each. The first group received water only and set as a control (GI). The second group received 20% fructose in drinking water daily (GII). Third group (GIII) received fructose 20% and 0. 25 mg/0.5 ml distilled water/kg body weight per day selenium in drinking water. After 5 weeks of supplementation, rats were sacrificed; blood samples were obtained for different biochemical analysis including serum level of glucose; lipids profile were measured including total cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and triglyceride (TG). Liver function tests, alanine transaminase (ALT), aspartate transaminase (AST), albumin and total protein were carried out. Also, kidney function tests (creatinine, urea and uric acid) were estimated in serum. The present study revealed that selenium treatment mitigate the complications associated with metabolic syndrome. It is recommended that selenium may be an important part of an individual medical nutritional and lifestyle intervention.

 

Key words: Fructose, metabolic syndrome, selenium, glucose, lipids profile, liver functions, kidney functions.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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