International Journal of
Plant Physiology and Biochemistry

  • Abbreviation: Int. J. Plant Physiol. Biochem.
  • Language: English
  • ISSN: 2141-2162
  • DOI: 10.5897/IJPPB
  • Start Year: 2009
  • Published Articles: 103

Full Length Research Paper

Cassava cyanocarbohydrate metabolism and proposed prehistoric symbionts

Van K. Golay
5761 N.E. 17 Av. Fort Lauderdale, Fl. 33334 USA.
Email: [email protected]

  •  Accepted: 14 February 2012
  •  Published: 31 March 2012

Abstract

Plant/animal symbiosis produces interacting plant food parts that bear selective pressure to produce specific behaviors that aid the plant’s reproduction and/or survival. The cassava plant is here proposed to have created such a transactional food part in the cyanogenic carbohydrate tubers that acts through a sirtuin-activating pathway. The effect of exclusive cassava cyanocarbohydrate metabolism at the cellular level is to utilize the methylglyoxal bypass of glycolysis. In doing so, deleterious triose-phosphate generated methylglyoxal is dismutated to metabolites necessary for simultaneous glycolysis (inorganic phosphate and NAD). That steady high rate of NAD supply drives gradual systemic sirtuin-activation on an exclusive cassava root diet as it progresses over 1 to 7 days. Clearing the large intestine of other foods (circa 5 to 7 days) correlated with maximal expression of the Sirt1 gene dependant increased physical activity phenotype in personal testing. A rational for such a mechanism is that proposed which involves prehistoric symbionts that coevolved with the cassava plant up until the megafauna extinctions 10,000 years ago.

 

Key words: Cyanogenic glucosides, methylglyoxal dismutation, cassava, symbionts, sirtuin Sirt1, colon microflora, pectin.

Abbreviation

SCFA, Short chain fatty acid; Daf-16, nematode abnormal dauer formation; IPA, increased physical activity; Sirt1, human silent information regulator1; HDAC, histone deacetylase; NAD, nicotinamide adenine dinucleotide; NADH, reduced NAD; NADPH, nicotinamide adenine dinucleotide phosphate reduced; AceCS, human acetyl CoA synthetase. 

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