Full Length Research Paper
Abstract
Four organotin(IV) carboxylate complexes derivative of 4-(diethylamino)benzoic acid have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their in vitro antibacterial screening activity. Monomeric {4-[N(C2H5)2]C6H4COO}2(R)2Sn (R = methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H5)3Sn 4 are obtained in solid state. The tin atom of complex 2 is six-coordinated, complex 4 is four-coordinated and the tin atoms of complex 3 are five and six-coordinated. With the exceptional case of tin atom of complex 1 exhibited five and six coordination in solution state which may be attributed from the dynamic stage or partial disassociation bonding of carboxylate anion. From the in vitro antibacterial screening activities, complex 1 is active against all the five tested bacterial strains compared to complexes 2 - 4.
Key words: Organotin(IV) complexes, synthesis, characterization, antibacterial activity.
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