International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2557

Full Length Research Paper

Synthesis and characterization of organotin(IV) complexes derived of 4-(diethylamino) benzoic acid: In vitro antibacterial screening activity

Yip-Foo Win1*, Siang-Guan Teoh2, M. R. Vikneswaran2, Sie-Tiong Ha1 and Pazilah Ibrahim3
1Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia. 2School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia. 3School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia.
Email: [email protected], [email protected]

  •  Published: 04 August 2010


Four organotin(IV) carboxylate complexes derivative of 4-(diethylamino)benzoic acid have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their in vitro antibacterial screening activity. Monomeric {4-[N(C2H5)2]C6H4COO}2(R)2Sn  (R = methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H5)3Sn  4 are obtained in solid state. The tin atom of complex 2 is six-coordinated, complex 4 is four-coordinated and the tin atoms of complex 3 are five and six-coordinated. With the exceptional case of tin atom of complex 1 exhibited five and six coordination in solution state which may be attributed from the dynamic stage or partial disassociation bonding of carboxylate anion. From the in vitro antibacterial screening activities, complex 1 is active against all the five tested bacterial strains compared to complexes 2 - 4.


Key words: Organotin(IV) complexes, synthesis, characterization, antibacterial activity.