International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2570

Full Length Research Paper

Identifying genes related with non-small cell lung cancer via transcription factors-target genes relationship

Wei-Dong Zang1, Jian Liu2, Li-Shan Wang1 and Tie-Wen Pan3*
  1Shanghai Jiaotong University, 800 Road, Shanghai 200241, China. 2Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030, USA. 3Changzheng Hospital of Second Military Medical University, Shanghai 200003, China.
Email: [email protected]

  •  Accepted: 22 August 2011
  •  Published: 09 November 2011

Abstract

 

The developments of gene expression profiling technology have deeply influenced the understanding of lung cancer biology. By microarray data, we constructed a regulation network to identify potential genes that are highly correlated to non-small cell lung cancer. Of the network, some transcription factors and target genes, including perturbation factors (PPARG), ETV4, TGFBR2 and ATP2A2, have been proved to be related to non-small cell lung cancer in previous study. We also found some new transcription factors and target genes may be related to non-small cell lung cancer, including SPI-1/PU.1, ETS2, and EGR1 and so on; these genes may be potential markers for non-small cell lung cancer.

 

Key words: Non-small cell lung cancer, transcription factors, regulation network.

 

Abbreviation

SCLC, Small-cell lung cancer: TRED, transcriptional regulatory element database; DEGs, differentially expressed genes; GO, gene ontology; IF, impact factor; PFs, perturbation factors; PPARG, PPARgamma; NSCLC, non-small cell lung cancer; VEGF-A, vascular endothelial growth factor-A; VWF, von Willebrand factor; ABC, ATP-binding cassette.