International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2572

Full Length Research Paper

Co-crystal structure of mixed molecules

Abdul Amir H. Kadhum2, Ahmed A. Al-Amiery1,2*, Hamdan A. Aday1, Yasamin K. Al-Majedy Ali A. Al-Temimi1, Redah I. Al-Bayati3 and Abu Bakar Mohamad2    
1Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia. 2Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq.    
Email: [email protected]

  •  Accepted: 13 January 2012
  •  Published: 02 March 2012


Based on the fundamentals of organic chemistry, the approach leads to the corresponding amides in good yields which were the reaction of esters with primary amines. In our laboratory, there was no reaction when we tried to react methyl 2-(2-oxo-2H-chromen-7-yloxy)acetate with 2-(2-aminophenyl) benzothiazole). Although the spectral data was so enough for validation of the structure of the product but in the thin layer chromatography (TLC) test, there still appear two spots for the reactant (no reaction); so only X-ray single crystallography will solve this problem and identify the structure of this shiny light brown crystal. Co-crystal structure was synthesized in methanolic solution from methyl 2-(2-oxo-2H-chromen-7-yloxy)acetate and 2-(2-aminophenyl)benzothiazole). Single X-ray crystallography was studied and it was found that there was no hydrogen bonding between the molecules, moreover, the co-crystal is very stable.


Key words: 2-(2-aminophenyl)benzothiazole), co-crystal, coumarins, methanol, single-crystal X-ray.