Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 288

Full Length Research Paper

Incidence of mother-child transmission of HIV-1 in the departments of Mono and Couffo in Benin: The associated factors in 2019

Hornel Koudokpon
  • Hornel Koudokpon
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Victorien Dougnon
  • Victorien Dougnon
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Setondji Islamiath Kissira
  • Setondji Islamiath Kissira
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Jean-Pierre Gnimatin
  • Jean-Pierre Gnimatin
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Alida Oussou
  • Alida Oussou
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Reine Tossa
  • Reine Tossa
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Gilbert Degbelo
  • Gilbert Degbelo
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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Lamine Baba-Moussa
  • Lamine Baba-Moussa
  • Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology, University of Abomey-Calavi, UAC, 05 P. O. Box 1604, Cotonou, Benin.
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Clement Ahoussinou
  • Clement Ahoussinou
  • Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin, 01 P. O. Box 2009, Cotonou, Benin.
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  •  Received: 27 April 2021
  •  Accepted: 07 June 2021
  •  Published: 31 May 2022

Abstract

Despite the worldwide success of the introduction of human immunodeficiency virus (HIV) testing and treatment with antiretroviral drugs, HIV remains a real public health problem. Vertical mother-to-child transmission is a form responsible for many cases of new infections. The objective of the study is to carry out an inventory of mother-to-child transmission of HIV-1 in the departments of Mono and Couffo. A total of 374 drops of dry blood (DBS) were collected from infants born to HIV-positive mothers during the year 2019. Information on the type of treatment, the type of infant diet was also collected. These different samples were used for RNA extraction. The early diagnosis of these infants as well as the determination of the viral load were carried out by reverse transcriptase-Polymerase Chain Reaction (RT-PCR) using the Roche automated system. The results showed that 93.41% of the newborns included in this study tested negative for early detection by RT-PCR. Significant associations were observed between early diagnosis of newborns and maternal feeding pattern, PMTCT protocol, and maternal viral load with regression logistics and Chi-square testing. Monoprophylaxis was predominant in the protocol for the prevention of neonatal mother-to-child transmission (PMTCT) (96.28%). The national program for the prevention of vertical transmission of HIV from mother to child deserves to be continued and strengthened with the objective of zero newborns infected at birth in the departments of Mono and Couffo.

Key words: HIV1, HIV-positive mothers, newborns, associated factors.

Abbreviation

HIV, Human immunodeficiency virus; DBS, dry blood spots; EDTA, ethylene diamine tetra acetic; RT-PCR, reverse transcriptase-polymerase chain reaction; PMTCT, prevention of mother-to-child transmission; CIPEC (in French), Support Center for People Living with HIV; OR, odds ratio; WHO, word health organization.