Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 283

Full Length Research Paper

Upregulation of interleukin-27 expression is correlated with higher CD4+ T cell counts in treatment of naive human immunodeficiency virus-infected Chinese

Lai He
  • Lai He
  • Faculty of Medicine, Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health and Primary Care; The Chinese University of Hong Kong, Hong Kong, China.
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Jin Zhao
  • Jin Zhao
  • Shenzhen Center for Disease Control and Prevention, Shenzhen, China.Faculty of Medicine, Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health and Primary Care; The Chinese University of Hong Kong, Hong Kong, China.
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Yong-Xia Gan
  • Yong-Xia Gan
  • Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
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Lin Chen
  • Lin Chen
  • Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
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Ming-Liang He
  • Ming-Liang He
  • Faculty of Medicine, Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health and Primary Care; The Chinese University of Hong Kong, Hong Kong, China.Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong, Kong, China.
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  •  Published: 31 January 2010

Abstract

Human immunodeficiency virus (HIV) infection is a major global health problem and causes a huge number of deaths each year. Interleukin-27 (IL-27), which is composed of Epstein Barr virus-induced gene 3 (EBI3) protein and p28 protein, inhibits HIV replication in vitro. However, the status of IL27 and its relationship with CD4+ T cell counts in vivo in treatment-naïve HIV infected individuals has not yet investigated. We recruited 108 healthy and 120 HIV-infected but treatment-naive Chinese individuals to participate this study in the last two years. We determined the IL-27 titers in all the participants by using enzyme-linked immunosorbent assay (ELISA), and measured the CD4+ T cell counts in HIV-infected individuals by using fluorescence activated cell sorting (FACS) assays. We showed that IL-27 titers were significantly elevated in HIV-infected individuals as compared to HIV negative healthy controls (612 ± 355 pg/ml vs 413 ± 230 pg/ml; P < 0.001). We also showed a significant positive correlation between plasma IL-27 titers and CD4+ T cell counts (r = 0.206, P = 0.024) in HIV-infected individuals. These findings suggest that the elevated plasma IL-27 levels may play important role in slowing down the CD4+ T cell declining in HIV-infected individuals and the process of AIDS disease.

 

Key words: Hu