Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 283

Full Length Research Paper

Antiretroviral therapy and genetic predisposition: Cofactors contributing to the lipodystrophy syndrome

Supriya D. Mahajan*
  • Supriya D. Mahajan*
  • Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York, Clinical Translational Research Center, 875 Ellicott St, Buffalo, NY 14203, USA.
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Srikanth Tripathy
  • Srikanth Tripathy
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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Jayanta Bhattacharya
  • Jayanta Bhattacharya
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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Asmita Gaikwad
  • Asmita Gaikwad
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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Jyoti Pawar
  • Jyoti Pawar
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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Manisha Ghate
  • Manisha Ghate
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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Ramesh Paranjape
  • Ramesh Paranjape
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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R. R.Gangakhedkar
  • R. R.Gangakhedkar
  • National AIDS Research Institute, Indian Council of Medical Research, G-73, MIDC, Bhosari, Pune 411026, India.
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  •  Received: 14 April 2014
  •  Accepted: 19 August 2014
  •  Published: 31 August 2014

Abstract

The TNF-α-238G/A single nucleotide polymorphism (SNP) independently increases the risk of lipodystrophy progression. The current study evaluates the contribution of the different antiretroviral treatments (ART) regimens administered to HIV infected individuals in Pune to the development of lipodystrophy and insulin resistance in patients having TNF-α-238G/A polymorphism. A total of 172 HIV-1 infected patients were enrolled in the study and were subdivided into patients with [HIV+LIPODYS+ (cases)] and without lipodystrophy [HIV+LIPODYS- (controls)]. We assessed the contribution of the typical 2NRTI+1 NNRTI based ART regimens prescribed in our clinics with the development of dyslipidemia and insulin resistance in both the above study group. A significantly higher percentage of patients with lipodystrophy expressed the TNF-α-238G/A polymorphism. Significant correlations were observed between Adiponectin, TNF-α protein levels and type of ART-ART regimen. Our results showed that the NNRTI efavirenz contributed more to the lipodystrophy syndrome as compared to other antiretroviral drugs tested. The TNF-α 238G/A SNP contributes to changes in insulin sensitivity and lipodystrophy.

 

Key words: HIV-1, antiretroviral drugs, single nucleotide polymorphism, lipodystrophy, dyslipidemia, adiponectin, insulin resistance, metabolic syndrome.

Abbreviation

ART, Antiretroviral therapy; SNP, single nucleotide polymorphism; PI’s, protease inhibitors; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitors; EFV, efavirenz; ZDV, zidovudine; NVP, nevirapine; HOMA, homeostatic model assessment; IR, insulin resistance.