Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 299

Full Length Research Paper

Effect of combination therapy of haart and α-zam herbal preparation for HIV infection in rats

Onifade A. A.
  • Onifade A. A.
  • Faculty of Health and Social Care, St George’s University of London and Kingston University, London.Chemical Pathology and Pharmacology Departments, College of Health Sciences, Igbinedion University Okada, Edo state, Nigeria.
  • Search for this author on:
  • Google Scholar
Jewell A. P
  • Jewell A. P
  • Faculty of Health and Social Care, St George’s University of London and Kingston University, London.
  • Search for this author on:
  • Google Scholar
Okesina A. B.
  • Okesina A. B.
  • Osun state University, Osogbo, Nigeria.
  • Search for this author on:
  • Google Scholar
Yong K.
  • Yong K.
  • Haematology Department, University College, London, UK.
  • Search for this author on:
  • Google Scholar
Ojezele M.
  • Ojezele M.
  • Chemical Pathology and Pharmacology Departments, College of Health Sciences, Igbinedion University Okada, Edo state, Nigeria.
  • Search for this author on:
  • Google Scholar
Nwanze J. C.
  • Nwanze J. C.
  • Chemical Pathology and Pharmacology Departments, College of Health Sciences, Igbinedion University Okada, Edo state, Nigeria.
  • Search for this author on:
  • Google Scholar
Saka G. O.
  • Saka G. O.
  • Chemical Pathology and Pharmacology Departments, College of Health Sciences, Igbinedion University Okada, Edo state, Nigeria.
  • Search for this author on:
  • Google Scholar
Sule W. F.
  • Sule W. F.
  • Osun state University, Osogbo, Nigeria.
  • Search for this author on:
  • Google Scholar
Aladekamika S. T.
  • Aladekamika S. T.
  • Morbid Anatomy Department, LAUTECH Teaching Hospital, Osogbo, Nigeria.
  • Search for this author on:
  • Google Scholar
Ajao A.
  • Ajao A.
  • Chemical Pathology and Pharmacology Departments, College of Health Sciences, Igbinedion University Okada, Edo state, Nigeria.
  • Search for this author on:
  • Google Scholar


  •  Accepted: 13 January 2011
  •  Published: 28 February 2011

Abstract

It is not uncommon seeing patients taking orthodox and herbal remedies concurrently for the same disease. The concern of many health practitioners is the safety of such combination therapy especially when there is a possibility of adverse drug reaction as a result of drug-drug interaction. This study focussed on drug interactions of α-Zam (herbal antiretroviral drug) when combined with lamivudine, zidovudine and nevirapine (highly active anti-retroviral therapy) using an animal model. Wistar rats were divided into 5 groups (10 rats per group) and were administered with 400 mg/kg (α-Zam), 800 mg/kg (α-Zam), 400 mg/kg (α-Zam) +HAART, 800 mg/kg (α-Zam) +HAART and normal saline. All administration was done once daily orally via canula to the 4 different groups respectively with the 5th group as control for 6 days. All wistar rats in all groups were observed daily for change in behaviour. On the 7th day, all rats were bled via retro-orbital plexus under light diethyl ether anaesthesia. The blood samples were analysed for haematological (haemoglobin concentration, white blood cell, red blood cell, platelet and lymphocyte counts) and biochemical (electrolytes, urea, creatinine, lipid profile, liver and renal functions tests) parameters. Some organs were also harvested for histological examinations. There was neither mortality nor behavioural abnormality observed in all the drug administered rats. There were some mild atrophic changes in liver and kidney with hyper-cellularity of bone marrow but no statistically significant difference (P>0.05) were found in all blood (haematological and biochemical) parameters in rat groups administered combination therapy (herbal concoction+ HAART). It was concluded that the combined administration of α-zam and HAART (lamivudine, zidovudine and nevirapine) did not cause any significant adverse drug reaction. Rather beneficial effects were observed in amelioration of side-effects associated with the herbal concoction and orthodox anti-viral medicines.

 

Key words: Combination therapy, HAART, α-Zam herbal remedy.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 3 No. 2
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES