Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 297

Article in Press

Fertility status of naïve human immunodeficiency virus-infected premenopausal females

Ogalagu R.O. and Alumanah E.O.

  •  Received: 18 December 2020
  •  Accepted: 30 April 2021
This study was aimed at evaluating the fertility status of naive Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome - infected females of child bearing age. The medical Ethical Committee of the University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, approved the study and the patients’ informed consents were obtained prior to sample collection. The subjects used in the study were 80 HIV- positive females aged between twenty to thirty five years at the PEPFAR, HIV clinic, UNTH, Enugu. Samples from 80 apparently healthy non-HIV positive age-matched female volunteers served as the control group. The blood samples were collected using standard methods. HIV re-screening and confirmation were carried out using WHO HIV test algorithm. Automated method using Flow cytometry was used for the enumeration of CD4+ T Lymphocytes while hormone analyses were carried out using competitive ELISA methods. In this study, serum oestradiol and progesterone levels of the patients were significantly lower (p< 0.001) than that of the control. Their respective levels in patients with CD4 ? 500 cells/µl, however, showed no significant difference (p>0.05) respectively when compared with the control. The blood CD4 count of the patients showed a significant decrease (p <0.001) compared with the control.The intra-batch variation for serum oestradiol and progesterone were 0.53 % and 1.30 % respectively while their respective inter-batch variations were 1.40 % and 6.8 %.

Keywords: Progesterone, oestrogen, CD4+ - T lymphocytes and Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome - infected, HIV/AIDS.