Creating a high-throughput screening database to propose ligands capable of modulating the HIV-1 protease receptor
This is a report of a de novo design study that aimed to identify novel structures capable of inhibiting the human immune deficiency virus (HIV-1) protease ligand binding pocket (HIV-1 PR_LBP). Baseline information regarding ligand binding modality and affinity was obtained through analysis of the pdb crystallographic depositions describing the HIV-1 PR enzyme complexed with small molecule inhibitors currently...
Assessment of potential risky sexual behaviors among Dilla University students: A survey study for enhancing self- protection from human immunodeficiency virus (HIV) infection
The aim of this research was to examine risky sexual behaviors and pre-disposing factors among Dilla University undergraduate students and to design feasible strategies to mitigate acquired immunodeficiency syndrome (AIDS) and other sexually transmitted diseases. Mainly, a qualitative method of data collection was utilized to get a number of 187 participants (181 regular students and 6 academically dismissed...
Geriatric human immune deficiency virus (HIV) Infection in Nigeria: A caseâ€series report
This study involves a caseâ€series of 3 elderly male patients with human immune deficiency virus (HIV) infection managed between 2009 and 2010 at the antiretroviral clinic (ART) University of Ilorin Teaching Hospital, Nigeria. They were all within the age range of 73 to 100 years and had multiple sexual partners. They were also coâ€managed for hypertension, diabetes mellitus and benign prostatic hyperplasia. Baseline...
Gaps in preventing mother to child transmission (PMTCT) and human immune deficiency virus (HIV) exposure among infants in a Nigerian City: Implications for health systems strengthening
In many countries, paediatric human immune deficiency virus (HIV) has been virtually eliminated. Nigeria however still records an unacceptably high number of HIV positive births. This study aims to identify HIV exposure rates among infants and to quantify gaps in preventing mother to child transmission (PMTCT) services in a major Nigerian city. A cross-sectional design was used to assess the prevalence of HIV...
Predictors of intended infant feeding options among HIV positive pregnant women in Addis Ababa: The perspective of theory of planned behavior
Although exclusive breast feeding during the first six months of life or replacement feeding are crucial in prevention of mother to child transmission of human immune deficiency virus (HIV), mothers intention on feeding options remain unstudied in Ethiopia. Therefore, this study was intended to assess HIV positive pregnant women’s intention towards infant feeding options. The data were collected from 196 HIV...
Pre-exposure prophylaxis in sero-discordant male partners of human immune deficiency virus (HIV) positive women desirous of natural conception â€“ a clinical setting experience
The reproductive health needs of sero-discordant couples are issues of concerns, especially in view of high cost of various assisted conception methods in the low-resource economies. Often times, many of these couples resort to un-informed and unsafe practices of unprotected heterosexual intercourse, leading to human immune deficiency virus (HIV) acquisition. The magnitude of the health burden of these populations in...