Journal of
Biophysics and Structural Biology

  • Abbreviation: J. Biophys. Struct. Biol.
  • Language: English
  • ISSN: 2141-2200
  • DOI: 10.5897/JBSB
  • Start Year: 2009
  • Published Articles: 25

Full Length Research Paper

Possible role of 2, 2’- (Diazinodimethylidyne) di - (o-phenylene) dibenzoate, a novel hydrazine as an anti – HIV agent

Rita Ghosh*, Dipanjan Guha, Sudipta Bhowmik and Angshuman Bagchi
Department of Biochemistry and Biophysics, University of Kalyani, Kalyani –741235, W. B., India.
Email: [email protected], [email protected]

  •  Accepted: 07 May 2010
  •  Published: 31 July 2010


A number of anti-HIV agents act by inhibiting specific steps in the lifecycle of HIV.  Inhibition of reverse-transcriptase (RT), a multi-functional enzyme is an important option. The interaction of 2, 2´-(Diazinodimethylidyne)-di-(o-phenylene)-dibenzoate (HZ) with HIV1-RT was studied to explore its possible use in anti-HIV therapy. This novel hydrazine derivative undergoes strong interaction with a number of amino acid residues present in its catalytic domain, some of which are catalytically important like Asp-110, Asp-185 and Asp-186: significant among them is the Asp-186 residue that is highly conserved. Our studies may be useful in the field of structure based drug development in anti HIV therapy.


Key words: HIV 1, drug development, NNRTI, Hydrazine derivative, molecular modelling.