A brief account of discovery of cancer therapy by overcoming the negative immune regulation of cancerous antigens (proteins) with cloned antibodies (proteins) for which Nobel Prize was awarded in Physiology or Medicine in 2018 has been analytically discussed here. These antibodies are now regarded as checkpoint inhibitors. These discoveries have opened a new channel for better treatment of different types of cancer. In view of these successful endeavours, attempts have been taken by the author to explain the functioning of both curative and immune role of certain antibodies (proteins) like MDX010, Nivolum ab and pembrolizum ab against cancer causing antigens like CTLA 4, PD 1, PDL 1, PDL 2 etc in the context of “Protein vibration”. A short note on the role of protein vibration has also been discussed here.

Keywords: Immune responses, Blockades, Cancerous antigens, Cloned antibodies, T cell receptors, Co stimulation, Inhibitors.