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References
Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265. |
|
Becker KG, Barnes KC, Bright TJ, Wang SA (2013). Genetic Association Database Available at http://geneticassociationdb.nih.gov/. Accessed June 2013. |
|
Bitanihirwe BK, Cunningham MG (2009). Zinc: the brain's dark horse. Synapse 63: 1029. |
|
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S, Cherry JM, Synder M (2013). Regulome DB: Annotation of functional variation in personal genomes. Available at: http://www.regulomedb.org/. Accessed June 2013. |
|
Brown G, Wallin C, Tatusova T, Pruitt K, Maglott D (2013). Gene: Integrated Access to Genes of Genomes in Reference Sequence Collection. Available at: http://www.ncbi.nlm.nih.gov/gene.Accessed June 2013. |
|
Chen J, Sun M, Kent WJ, Huan X, Xie H, Wang W, Zhou G, Shi RZ, Rowley JD (2004). Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res. 32: 4812-4820. |
|
Classen HG, Grober U, Low, D, Schmidt J, Stracke H (2011). Zinc deficiency: symptoms, causes, diagnosis and therapy. Med. Monatsschr. Pharm. 34:87-95. |
|
David L, Huber W, Granovskaia M, Toedling J, Palm CJ, Bofkin L, Jones T, Davis RW, Steinmetz LM (2006). A high-resolution map of transcription in the yeast genome. Proc. Natl. Acad. Sci. USA 103: 5320-5325. |
|
Dunston G, Mason TE, Hercules W, Lindesay J (2014). Single Nucleotide Polymorphisms: A Window into the Informatics of the Living Genome. Adv. Biosci. Biotechnol. 5:623-626. |
|
Dupont CL, Butcher A, Valas RE, Bourne PE, Caetano-Anolles G (2010). History of biological metal utilization inferred through phylogenomics analysis of protein structures. Proc. Natl. Acad. Sci. USA 107:10567-10572. |
|
Enerly E, Sheng Z, Li KB (2005). Natural antisense as potential regulator of alternative initiation, splicing and termination. In Silico Biol. 5: 367-377. |
|
Fabris N, Mocchegiani E (1995). Zinc, human diseases and aging. Aging 7:77-93. |
|
Frausto da Silva JJR, Williams RJP (2001). The Biological Chemistry of the Elements. Oxford University Press, Oxford. |
|
Friedman RC, Farh KK, Burge CB, Bartel DP (2014). TargetScan Human: Prediction of microRNA targets. Available at: http://www.targetscan.org/vert_61/. Accessed July 2014. |
|
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Copper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002). The Structure of Haplotype Blocks in the Human Genome. Science 296:2225-2229. |
|
Gagen MJ and Mattick JS (2005). Accelerating, hyperaccelerating, and decelerating networks. Phys. Rev. E. Nonlin. Soft Mattter Phys. 72:016123. |
|
Genome Bioinformatics Group of UC Santa Cruz (2013). UCSC Genome Browser. Available at: https://genome.ucsc.edu/. Accessed June 2013. |
|
Greer L, Domrachev M, Lipman DJ, Bryant SH (2014). Conserved Domain Architecture Retrieval Tool. Available at: http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi. Accessed July 2014. |
|
Hardy GH (1908). Mendelian proportions in a mixed population. Science 28:49-50. |
|
Havilio M, Levanon EY, Lerman G, Kupiec M, Eisenberg E (2005). Evidence for abundant transcription of non-coding regions in the Saccharomyces cerevisiae genome. BMC Genomics 6: 93. |
|
Hindorff LA, MacArthur J (European Bioinformatics Institute), Morales J (European Bioinformatics Institute), Junkins HA, Hall PN, Klemm AK, Manolio TA (2013). A Catalog of Published Genome-Wide Association Studies. Available at: www.genome.gov/gwastudies. Accessed June 2013. |
|
Imamura T, Yamamoto S, Ohgane J, Hattori N, Tanaka S, Shiota K (2004). Non-coding RNA directed DNA demethylation of Sphk1 CpG island. Biochem. Biophys. Res. Commun. 3: 593-600. |
|
Jen CH, Michalopoulos I, Westhead DR, Meyer P (2005). Natural antisense transcripts with coding capacity in Arabidopsis may have a regulatory role that is not kinked to double-stranded RNA degradation. Genome Biol. 6:R51. |
|
Khochbin S, Brocard MP, Grunwald D, Lawrence JJ (1992). Antisense RNA and p53 regulation in induced murine cell differentiation. Ann. NY Acad. Sci. 660:77-87. |
|
Kiyosawa H, Mise N, Iwase S, Hayashizaki Y, Abe K (2005). Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized. Genome Res. 15:463-474. |
|
Kiyosawa H, Yamanaka I, Osato N, Kondo S, Hayashizaki Y, RIKEN GER Group, GSL Members (2003). Antisense transcripts with FANTOM2 clone set and their implications for gene regulation. Genome Res. 13: 1324-1334. |
|
Krystal GW, Armstrong BW, Battey JF (1990). N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol. Cell Biol. 10:4180-4191. |
|
Kumar M, Carmichael GG (1997). Nuclear antisense RNA induces extensive adenosine modification and nuclear retention of target transcripts. Proc. Natl. Acad. Sci. USA 94: 3542-3547. |
|
Lapidot M, Pilpel Y (2006). Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms. EMBO reports 7: 1216-1222. |
|
Lee JT, Davidow LS and Warshawsky D (1999). Tsix, a gene antisense to Xist at the X-inactivation centre. Nat. Genet. 21: 400-404. |
|
Lee PH and Shatkay H. F-SNP: Computationally predicted functional SNPs for disease association studies. Available at: http://compbio.cs.queensu.ca/F-SNP/. Accessed June 2013. |
|
Li JT, Zhang Y, Kong L, Liu QR, Wei L (2008). Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation. Nucleic Acids Res. 35:4833-4844. |
|
Li YY, Qin L, Guo ZM, Liu L, Xu H, Hao P, Su J, Shi Y, He WZ, Li YX (2006). In silico discovery of human natural antisense transcripts. BMC Bioinformatics 7: 18. |
|
Lindesay J (2013). Foundations of Quantum Gravity. Cambridge University Press, Cambridge. |
|
Lindesay J, Mason TE, Ricks-Santi L, Hercules WM, Kurian P, Dunston GM (2012). A New Biophysical Metric for Interrogating the Information Content in Human Genome Sequence Variation: Proof of Concept. J. Comput. Biol. Bioinform. Res. 4:15-22. |
|
Mattick JS (2004). RNA regulation: a new genetics? Nat. Rev. Genet. 5:316-323. |
|
Mattick JS (2007). A new paradigm for developmental biology. J. Exp. Biol. 210:1526-1547. |
|
McCarthy TT, Zeelie JJ, Krause DJ (1992). The antimicrobial action of zinc ion/antioxidant combinations. Clin. Pharmacol. Ther. 17: 5. |
|
Mihola O, Forejt J, Trachtulec Z (2007). Conserved alternative and antisense transcripts at the programmed cell death 2 locus. BMC Genomics 8:20. |
|
Munroe SH, Lazar MA (1991). Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. J. Biol. Chem. 266: 22083-22086. |
|
Murakami M, Hirano T (2008). Intracellular zinc homeostasis and zinc signaling. Cancer Sci. 99:1515-1522. |
|
Chan WY, Wu SM, Ruzczyk L, Law E, Lee TL, Baxendale V, Lap-Ying Pang A, Rennert OM (2006). The complexity of antisense transcription revealed by the study of developing male germ cells. Genomics 87:681-692. |
|
Pang KC, Frith MC, Mattick JS (2006). Rapid evolution of non-coding RNAs: lack of conservation does not mean lack of function. Trends Genet. 22:1-5. |
|
Pfeiffer CC, Braverman ER (1982). Zinc, the brain and behavior. Biol. Psychiatry 17:513-532. |
|
Prasad AS (1995). Zinc: an overview. Nutrition 11:93-99. |
|
Qu Z, Adelson DL (2012). Evolutionary conservation and functional roles of ncRNA. Front. Genet. 3:1-11. |
|
Rosok O, Sioud M (2005). Systematic search for natural antisense transcripts in eukaryotes (review). Int. J. Mol. Med. 15: 197-203. |
|
Rossignol F, Vache C, Clottes E (2002). Natural antisense transcripts of hypoxia-inducible factor I alpha are detected in different normal and tumour human tissues. Gene 299:135-140. |
|
Sandelin A, Wasserman WW, Lenhard B (2013). ConSite: web-based prediction of regulatory elements using cross species comparison. Available at: https://genome.ucsc.edu/. Accessed June 2013. |
|
Sandstead HH (1994). Understanding zinc: recent observations and interpretations. J. Lab. Clin. Med. 124: 322-327. |
|
Scherbakov DV, Garber MB (2000). Overlapping Genes in Bacterial and Phage Genomes. Mol. Biol. 34:485-495. |
|
Sherry ST, Ward, MH, Kholdov M, Baker J, Phan L, Smigielski EM, Sirotkin K (2012). dbSNP: the NCBI database of genetic variation. Available at: http://www.ncbi.nlm.nih.gov/SNP/. Accessed December 2012. |
|
Sigrist CJA, de Castro E, Cerutti L, Cuche BA, Huo N, Bridge A, Bougueleret L, Xenarios I (2013). PROSITE: Database of protein domains, families and functional sites. Available at: http://prosite.expasy.org/. Accessed June 2013. |
|
Sleutels F, Barlow DP, Lyle R (2000). The uniqueness of the imprinting mechanism. Curr. Opin. Genet. Dev.10:299-233. |
|
Solomons NW (1998). Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr. Rev. 56:27-28. |
|
Sun M, Hurst LD, Carmichael GG, Chen J (2006). Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptional organismic complexity. Genome Res. 16:922-933. |
|
Susskind L, Lindesay J (2005). An Introduction to Black Holes, Information and the String Theory Revolution. World Scientific Publishing Company, Hackensack. |
|
Taft RJ, Pheasant M, Mattick JS (2007). The relationship between non-protein-coding DNA and eukaryotic complexity. Bioessays 29:288-299. |
|
Thorisson GA, Smith AV, Krishnan L, Stein LD (2012). The International HapMap Project Website. Available at: http://hapmap.ncbi.nlm.nih.gov/. Accessed December 2012. |
|
Vallee BL, Auld DS (1993). Cocatalytic zinc motifs in enzyme catalysis. Proc. Natl. Acad. Sci. USA 90:2715-2718. |
|
Volk R, Koster M, Poting A, Hartmann L, Knochel W (1989). An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24kd protein. Embo. J. 8:2983-2988. |
|
Wang A, Yasue H, Li L, Takashima M, deLeon FA, Liu WS (2008). Molecular characterization of the bovine chromodomain Y-like genes. Anim. Genet. 39:207-216. |
|
Wang XJ, Gaasterland T, Chua NH (2005). Genome-wide prediction and identification of cis-natural antisense transcripts in Arabidopsis thaliana. Genome Biol. 6:R30. |
|
Wapnir RA (1990). Protein Nutrition and Mineral Absorption. CRC Press, Boca Raton. |
|
Weinberg W (1908). Über den Nachweis der Vererbung beim Menschen. Jahresh. Ver. Vaterl. Naturkd. Württemb. 64: 369–382. |
|
Williams RJP (2012). Zinc in evolution. J. Inorg. Biochem. 111:104-109. |
|
Williams RJP, Frausto da Silva JJR (2006). The Chemistry of Evolution. Elsevier, Amsterdam. |
|
Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW 3rd, Su AI (2013). BioGPS: An extensible and customizable portal for querying and organzing gene annotation resources. Available at: http://biogps.org/. Accessed June 2013. |
|
Yelin R, Dahary D, Sorek R, Levanon EY, Goldstein O, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, Nemzer S, Pinner E, walach S, Bernstein J, Savisky K, Rotman G (2003). Widespread occurrence of antisense transcription in the human genome. Nat. Biotechol. 21:379-386. |
|
Zhang Y and Gladyshev VN (2009). Comparative Genomics of Trace Elements: Emerging Dynamic View of Trace Element Utilization and Function. Chem. Rev. 109:4828-4861. |
|
Zhang Y, Li JT, Kong L, Gao G, Liu QR, Wei L (2013). NATs DB: Natural Antisense Transcripts Database. Available at: http://natsdb.cbi.pku.edu.cn/. Accessed June 2013. |
|
Zhang Y, Liu XS, Liu QR, Wei L (2006). Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species. Nucleic Acids Res. 34:3465-3475. |
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