Journal of
Clinical Immunology and Immunopathology Research

  • Abbreviation: J. Clin. Immunol. Immunopathol. Res.
  • Language: English
  • ISSN: 2141-2219
  • DOI: 10.5897/JCIIR
  • Start Year: 2009
  • Published Articles: 22

Full Length Research Paper

Differentiation of stem and progenitor cells in activated immune cells with anti-malignant properties

Iskra Ventseslavova Sainova
  • Iskra Ventseslavova Sainova
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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Ilina Vavrek
  • Ilina Vavrek
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
  • Google Scholar
Velichka Pavlova
  • Velichka Pavlova
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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Ivan Iliev
  • Ivan Iliev
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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Lilija Yossifova
  • Lilija Yossifova
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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Elena Gardeva
  • Elena Gardeva
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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Elena Nikolova
  • Elena Nikolova
  • Department of Experimental Morphology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, “Acad. G. Bonchev“ Str., 1113 Sofia, Bulgaria.
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  •  Accepted: 23 January 2012
  •  Published: 31 January 2012

Abstract

Studies on the biology of immune cells are mainly focused on their role as immune activators and modulators. In their appropriate cultivation and/or modifications, they have shown abilities for an enhanced expression of specific effective molecules. These properties have characterized them as promising candidates for construction of novel safe vaccines and gene-engineering products on their basis. In this aspect, in the last years, attention is directed towards the development of new safe therapeutic methods and techniques with immune cells. In this connection, according to results obtained, in vitro-co-cultivation derived by myeloid and lymphoid precursors with positive and negative on the additionally-inserted copy of the oncogene Dcn1 transfected cells, no immune reaction is observed against both genetically-manipulated cell types, which could be accepted as a proof for their safety. On the other hand, signs of increased degree for both myeloid and lymphoid differentiation in the presence of transfected cells, positive on additionally-inserted copy of the oncogen are indicated.

 

Key words: Progenitor cells, immune cell precursors, gene constructs, oncogenes, tumor-suppresser genes.