Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 106

Full Length Research Paper

Alteration in chemical composition of red blood cells in iron deficiency anemia

Neelima Hemkar
  • Neelima Hemkar
  • Department of Biochemistry, S. P. Medical College, Bikaner (Rajasthan), India.
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D. C. Sharma
  • D. C. Sharma
  • Department of Biochemistry, S. P. Medical College, Bikaner (Rajasthan), India.
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Manminder Riyat
  • Manminder Riyat
  • Department of Biochemistry, S. G. T. Dental College, Budhera, Gurgaon, (Haryana), India.
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  •  Accepted: 27 October 2009
  •  Published: 28 February 2010

Abstract

The alteration in the chemical composition of plasma in health and diseases is well studied, but the changes in interior milieu of erythrocytes are not properly explored. We have studied 15 parameters (carbohydrates, lipids, proteins, electrolytes / cations, anions, metabolites, iron compounds etc.). All the studied parameters were significantly decreased in iron deficient anemic erythrocytes, except inorganic phosphorus, which was actually increased significantly. Red cell’s intracellular concentrations of iron and ferritin were found to be better indicator of iron deficiency anemia than plasma iron and ferritin.

 

Key words: Anemia, iron deficiency, red cells, chemical composition.

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