Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 106

Full Length Research Paper

Role of GSTM1 gene polymorphism and its association with coronary artery disease

Rabbani Syed
  • Rabbani Syed
  • Genetics Department, Bhagwan Mahavir Medical Research Centre,10-1-1, Mahavir Marg, Hyderabad-500004 A. P., India.School of Biotechnology, Mahatma Gandhi National Institute of Research and Social Action Hyderabad, A. P. India.
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Farha Deeba
  • Farha Deeba
  • School of Biotechnology, Mahatma Gandhi National Institute of Research and Social Action Hyderabad, A. P. India.
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Kaiser Jamil
  • Kaiser Jamil
  • Genetics Department, Bhagwan Mahavir Medical Research Centre,10-1-1, Mahavir Marg, Hyderabad-500004 A. P., India.School of Biotechnology, Mahatma Gandhi National Institute of Research and Social Action Hyderabad, A. P. India.
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  •  Accepted: 29 September 2009
  •  Published: 28 February 2010

Abstract

Coronary artery disease (CAD) is one of the leading causes of mortality and morbidity worldwide. Complex interplay of environmental and genetic factors has been known to contribute to CAD pathophysiology. Variations in several genes have been found to be associated with risk for developing CAD in different populations. Glutathione S-transferases (GSTs) play a primer role in cellular defense against electrophilic chemical species and radical oxygen species. This study was designed to assess the GSTM1 gene variant in 120 patients with coronary artery disease (CAD) as compared to equal number of controls. DNA was isolated from the blood samples collected and subjected to PCR with specific GSTM1 specific primers. The frequency of GSTM 1 gene was in 73.3% of cases or patients with CAD and 61.6% in control subjects and the frequency of null genotype was 26.6% in CAD cases and 38.3% in control group. There was no significant association of GSTM1 gene (null) polymorphism (χ² = 3.72, P = 0.053, OR = 1.17, 95% CI = 0.95 – 3.07) with CAD in our study. However, diabetes and smoking were significantly associated with CAD (p <  0.001).

 

Key words: GSTM1, CAD, genetic polymorphism

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