Journal of
Evolutionary Biology Research

  • Abbreviation: J. Evol. Biol. Res.
  • Language: English
  • ISSN: 2141-6583
  • DOI: 10.5897/JEBR
  • Start Year: 2009
  • Published Articles: 32

Full Length Research Paper

Decreasing values, from the North of West Europe to North Africa, of 374F allele frequencies in the skin pigmentation gene SLC45A2: An analysis

Gérard Lucotte1* and Isao Yuasa²
1Institute of Molecular Anthropology, Paris, France. 2Division of Legal Medicine, Faculty of Medicine, Tottori University, Japan.
Email: [email protected]

  •  Published: 31 March 2011


The 374F mutation in the SLC45A2 gene encoding the membrane associated transporter protein (MATP) has been suggested to be associated with skin color in Caucasians. In this synthesis, we collected the distribution of the 374F allele in 2910 unrelated subjects from 28 European and 4 North African populations. The highest allele frequency was observed in Denmark (0.98) and the lowest frequencies were observed in Tunisia (0.61) and in Algerian Mozabites (0.40). A significant decreasing latitudinal cline in 374F allele frequencies was observed, ranging from the north of West Europe to North Africa (R² = 0.6781).

Key words: Human skin pigmentation, SLC45A2 gene, 374F mutation, membrane-associated transporter protein (MATP), population study, gradient of allele frequencies, West Europe and North Africa.