Journal of
Environmental Chemistry and Ecotoxicology

  • Abbreviation: J. Environ. Chem. Ecotoxicol.
  • Language: English
  • ISSN: 2141-226X
  • DOI: 10.5897/JECE
  • Start Year: 2009
  • Published Articles: 189

Full Length Research Paper

Determination of pharmaceutical compounds in surface and underground water by solid phase extraction-liquid chromatography

Olatunde James Olaitan
  • Olatunde James Olaitan
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Nigeria.
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Chimezie Anyakora
  • Chimezie Anyakora
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Nigeria.
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Tolulope Bamiro
  • Tolulope Bamiro
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu - Ogun State, Nigeria.
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Aminat Temitope Tella
  • Aminat Temitope Tella
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu - Ogun State, Nigeria.
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  •  Received: 06 February 2014
  •  Accepted: 24 June 2014
  •  Published: 30 June 2014

Abstract

A solid-phase extraction (SPE) followed by high performance liquid chromatography method was used for extraction and analysis of 4 pharmaceutical residues (Diclofenac, Chloroquine, Paracetamol and Ciprofloxacine HCl) in environmental water samples. This method was successfully applied to environmental water samples from Sango-Ota, a high industrial community in Ogun State, Nigeria, for the determination of the targeted pharmaceutical residues. The four calibration curves obtained were all linear with a correlation coefficient ranging from 0.997-0.999. Over-all average concentrations of the targeted pharmaceutical residues were 17.25, 5.01, 2.57 and 0.86 µg/L respectively. These results confirm the presence of such residues in our environment, hence, emphasising the need to bring to the knowledge of people, the danger of pharmaceuticals residues in the environment and the best method for the disposal of unused pharmaceuticals.

 

Key words:  Solid phase extraction, hplc, pharmaceuticals, groundwater, surface water.