Journal of
Microbiology and Antimicrobials

  • Abbreviation: J. Microbiol. Antimicrob.
  • Language: English
  • ISSN: 2141-2308
  • DOI: 10.5897/JMA
  • Start Year: 2009
  • Published Articles: 160

Full Length Research Paper

Vernodalinol isolated from Struchium sparganophora (Linn) Asteraceae

Kasim L. S.1*, Ukpo G. E.2 and Odukoya O. A.3
1Department of Pharmaceutical and Medicinal Chemistry, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria. 2Department of Pharmaceutical and Medicinal Chemistry, University of Lagos, Lagos State, Nigeria 3Department of Pharmacognosy, University of Lagos, Lagos State, Nigeria
Email: [email protected]

  •  Accepted: 29 September 2013
  •  Published: 31 October 2013

Abstract

Chemical investigation of anti-microbial and anti-fungal components of the leaves of Struchium sparganophora through the application of vacuum liquid chromatogtaphy (VLC), column liquid chromatography (CLC) and preparative thin layer chromatography (PTLC) resulted in isolation of a sesquiterpene lactone, vernodalinol. This compound was subjected to anti-fungal and cytotoxic tests. It exhibited a significant antifungal properties (P>.05) at the concentrations of 12.5 to 25 µg/ml and cytotoxic effects against melanoma and ovarian cancer cell lines at the concentrations of 3 - 5 x 10−3 µg/ml; the structure of this compound was determined by spectroscopic methods. This compound portend a useful chemotherapeutic agent in the treatment of fungal and cancer infections

Key words: Struchium sparganophora. Asteraceae, elemanolide lactone, vernodalinol.