Journal of
Microbiology and Antimicrobials

  • Abbreviation: J. Microbiol. Antimicrob.
  • Language: English
  • ISSN: 2141-2308
  • DOI: 10.5897/JMA
  • Start Year: 2009
  • Published Articles: 154

Full Length Research Paper

Prevalence of integrons in Enterobacteriaceae obtained from clinical samples

Joy Ndidiamaka Barns
  • Joy Ndidiamaka Barns
  • Department of Microbiology, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
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Cajethan Onyebuchi Ezeamagu
  • Cajethan Onyebuchi Ezeamagu
  • Department of Microbiology, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
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Munachimso Esther Nkemjika
  • Munachimso Esther Nkemjika
  • Department of Microbiology, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
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Tolulope Sherifat Akindele
  • Tolulope Sherifat Akindele
  • Department of Laboratory Technology, Abraham Adesanya Polytechnic, Ijebu-Igbo, Ogun State, Nigeria.
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  •  Received: 05 June 2020
  •  Accepted: 15 January 2021
  •  Published: 31 January 2021

Abstract

Multi-drug resistant bacteria are a public health problem associated with high morbidity and mortality globally. This increasing drug resistance has been linked to gene exchange between bacteria. Integrons are gene exchange systems and are known to play a significant role in the acquisition and dissemination of antimicrobial resistance genes especially in Gram negative bacteria. Hence, this study aims to evaluate integrons in members of Enterobacteriaceae obtained from clinical samples. Forty- nine (49) isolates identified as Escherichia coli (45), Proteus mirabilis (2), Shimwellia blattae (1), and Klebsiella pneumoniae (1) were resistant to amoxicillin/clavulanate, cefuroxime, cefixime and ceftazidime while 43(87.76%), 45(91.84%), 46(93.88%) and 29(59.18%) of these strains were resistant to gentamicin, ofloxacin, ciprofloxacin and nitrofurantoin, respectively. Class 1 integrons were found in E. coli (18), Klebsiella pneumoniae (1) and Proteus mirabilis (1). This study revealed that large proportion of the strains studied were multi-drug resistant, and possessed integrons. Consequently, there is a need for proactive antibiotic surveillance system in both healthcare and community settings with a view to reducing the incidence and spread of antibiotic resistance genes between different species of bacteria.

 

Key words: Enterobacteriaceae, clinical samples integrons, multidrug resistance.