Journal of
Microbiology and Antimicrobials

  • Abbreviation: J. Microbiol. Antimicrob.
  • Language: English
  • ISSN: 2141-2308
  • DOI: 10.5897/JMA
  • Start Year: 2009
  • Published Articles: 166


Potential pharmacological applications of enzymes associated with bacterial metabolism of aromatic compounds

Ranjith N. Kumavath*
  • Ranjith N. Kumavath*
  • Department of Genomic Sciences, School of Biological Sciences, Central University of Kerala, P.O. Central University, Kasaragod- 671314, India.
  • Google Scholar
Debmalya Barh
  • Debmalya Barh
  • Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, Nonakuri, PurbaMedinipur, West Bengal 721172, India.
  • Google Scholar
Vasco Azevedo
  • Vasco Azevedo
  • Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. MG, Brazil
  • Google Scholar
Alan Prem Kumar
  • Alan Prem Kumar
  • Cancer Science Institute of Singapore, National University of Singapore, Singapore
  • Google Scholar

  •  Received: 30 September 2015
  •  Accepted: 03 January 2016
  •  Published: 31 January 2017


Many purple anoxygenic bacteria contribute significantly to the catabolic and anabolic processes in the oxic/anoxic zones of several ecosystems. However, these bacteria are incapable of degrading the benzenoid ring during the biotransformation of aromatic hydrocarbons. The key enzymes in the aromatic amin acids metabolism of purple bacteria include 3,4-dihydroxyphenylalanine minotransferase (EC, 3,4-dihydroxyphenylalanine reductive deaminase (EC, 3,4- dihydroxyphenylalanine oxidative deaminase (EC, L-tryptophan aminotransferase (EC, 3,4-dihydroxyphenylalanine aminotransferase (EC, phenylalanine ammonia lyase (EC, tyrosine ammonia lyase (EC, phenylalanine/tyrosine ammonia lyase (EC, phenylacetate-CoA ligase (EC; histidine ammonia lyase (EC, tryptophanase (EC, tryptophan 2,3-dioxygenase (EC and kynurenineformidase (EC These enzymes have biological significance since these are known to have highly antioxidant, anti-cancer, anti HIV, antifungal/microbial, cyclooxygenase inhibitory phytohormonal activities and also display an impressive array of pharmacological applications viz. pigmenta, toxins, enzyme inhibitors, pesticides herbicides, antiparasitics, mycotoxins, antitumor agents, cytotoxic activities and growth promoter of animal and plants. Here, we reviewed anoxygenic bacterial novel enzymes and their biotechnological applications.

Key words:Alkylester, biotransformation, bioprospect, indigo, indolmycin, purple bacteria, violacein.