Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA)

Navarro-García Víctor Manuel1*, Salinas-Sánchez David Osvaldo1,2, Rodríguez-Flores Tannia Alejandra1, Abarca-Vargas Rodolfo1,3 and Aldana-Llanos Lucila4
1Laboratorio de Microbiología. Centro de Investigación Biomédica del Sur-Instituto Mexicano del Seguro Social (CIBIS-IMSS), Xochitepec, Morelos, Mexico. 2Departamento de Recursos Naturales del Centro de Investigación en Biodiversidad y Conservación (CIByC), Universidad Autónoma del Estado de México (UAEM), Cuernavaca, Morelos, Mexico. 3Laboratorio de Farmacología. Centro de Investigación Biomédica del Sur-Instituto Mexicano del Seguro Social (CIBIS-IMSS), Xochitepec, Morelos, Mexico. 4Laboratorio de Entomología, Centro de Desarrollo de Productos Bióticos (CENPROBI), Instituto Politécnico Nacional (IPN), Yautepec, Morelos, Mexico.
Email: [email protected]

  •  Accepted: 01 June 2012
  •  Published: 05 September 2012

Abstract

We evaluated the antibacterial activity of the organic extracts (n-hexane, acetone and methanol) from the fruit of Artocarpus heterophyllus Lam. against Staphylococcus aureus,(methicillin-susceptible Staphylococcus aureus [MSSA]). The extract that demonstrated the greatest activity was that of acetone, with a minimum inhibitory concentration (MIC) value of 0.375 mg/ml against S. aureus MSSA. The acetone extract was further fractionated by means of open-column chromatographic methods into different fractions, and it was found that the F3 fraction was the most active. An active compound against MSSA and methicillin-resistant Staphylococcus aureus bacteria was isolated from this fraction; this compound was identified through spectroscopic methods of 1H and 13C nuclear magnetic resonance as artocarpesin.

 

Key words: Antimicrobial activity, artocarpesin, Artocarpus heterophyllus, methicillin-resistant Staphylococcus aureus (MRSA).