Full Length Research Paper
Abstract
We evaluated the antibacterial activity of the organic extracts (n-hexane, acetone and methanol) from the fruit of Artocarpus heterophyllus Lam. against Staphylococcus aureus,(methicillin-susceptible Staphylococcus aureus [MSSA]). The extract that demonstrated the greatest activity was that of acetone, with a minimum inhibitory concentration (MIC) value of 0.375 mg/ml against S. aureus MSSA. The acetone extract was further fractionated by means of open-column chromatographic methods into different fractions, and it was found that the F3 fraction was the most active. An active compound against MSSA and methicillin-resistant Staphylococcus aureus bacteria was isolated from this fraction; this compound was identified through spectroscopic methods of 1H and 13C nuclear magnetic resonance as artocarpesin.
Key words: Antimicrobial activity, artocarpesin, Artocarpus heterophyllus, methicillin-resistant Staphylococcus aureus (MRSA).
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