Full Length Research Paper
Abstract
The different organic solvent extracts of roots of Dryneria quercifolia J. Smith were tested for their antibacterial activity and cytotoxicity. Chloroform and ethyl acetate extracts (150mg/disc) showed good antibacterial activity as determined by disc-diffusion method against four Gram-positive and six Gram-negative bacteria than petroleum ether extract. The minimum inhibitory concentration (MIC) of each extract was determined by serial dilution technique against Escherichia coli, Shigella dysenteriae, Salmonella typhi, Bacillus subtilisand Streptococcus-b-haemolyticus. The MIC values ranged from 16 to 64 mg/ml. The cytotoxicity of each extract was assessed by brine shrimp lethality bioassay and LC50values were determined. The LC50 values for petroleum, chloroform and ethyl acetate extracts were 22.0, 16.5 and 16.5 mg/ml, respectively. The positive results of these bioactive extracts should encourage the further investigation of the active principles responsible for these activities.
Key words: Dryneria quercifolia, antibacterial activity, minimum inhibitory concentration, cytotoxicity.
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