Five xanthones (1-5) were isolated from the heartwood of Anaxagorea luzonensis A. Gray (Annonaceae) and this is the first report of the isolation of xanthone 1 (6-deoxyisojacareubin) from this species. The in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of these isolated xanthones was highest in 1,3,5-trihydroxy-4-prenylxanthone (3) for both enzymes with IC50 values of 56.3±0.4 and 46.0±0.3 µM, respectively. The presence of the C-4 prenyl residue attached to the xanthone core co-orrelated significantly with the AChE and BChE inhibitory activities and was significantly reduced by hydroxylation (removal of the carbon double bond and addition of a hydroxyl group).
Key words: Anaxagorea luzonensis, Annonaceae, xanthone, acetylcholinesterase, butyrylcholinesterase.
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