Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3762

Full Length Research Paper

Cholinesterase inhibitory activities of xanthones from Anaxagorea luzonensis A. Gray

Chalisa Sabphon1, Thiendanai Sermboonpaisarn2 and Pattara Sawasdee2*
1Program of Biotechnology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand. 2Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand.
Email: [email protected]

  •  Accepted: 12 April 2012
  •  Published: 09 June 2012

Abstract

Five xanthones (1-5) were isolated from the heartwood of Anaxagorea luzonensis A. Gray (Annonaceae) and this is the first report of the isolation of xanthone 1 (6-deoxyisojacareubin) from this species. The in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of these isolated xanthones was highest in 1,3,5-trihydroxy-4-prenylxanthone (3) for both enzymes with IC50 values of 56.3±0.4 and 46.0±0.3 µM, respectively. The presence of the C-4 prenyl residue attached to the xanthone core co-orrelated significantly with the  AChE and BChE inhibitory activities and was significantly reduced by hydroxylation (removal of the carbon double bond and addition of a hydroxyl group).
 

Key words: Anaxagorea luzonensis, Annonaceae, xanthone, acetylcholinesterase, butyrylcholinesterase.