Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Phytochemical screening, anti-inflammatory and immunomodulatory activities of Acanthospermum hispidum and Croton zambesicus collected in the Republic of Benin

Paulin Kpodji
  • Paulin Kpodji
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Gatien Lokossou
  • Gatien Lokossou
  • Department of Human Biology Engineering, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Benin.
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Victorien Dougnon
  • Victorien Dougnon
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Phénix Assogba
  • Phénix Assogba
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Alidehou Jerrold Agbankpé
  • Alidehou Jerrold Agbankpé
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Esther Déguénon
  • Esther Déguénon
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Gérardo Agbaka
  • Gérardo Agbaka
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Expédit Yéhouénou
  • Expédit Yéhouénou
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Tatiana Hountohotègbè
  • Tatiana Hountohotègbè
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Jean-Robert Klotoé
  • Jean-Robert Klotoé
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Kévin Sintondji
  • Kévin Sintondji
  • Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Abomey-Calavi, Benin.
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Lamine Baba-Moussa
  • Lamine Baba-Moussa
  • Laboratory of Biology and Molecular Typing in Microbiology, éééééFaculty of Science and Technology, University of Abomey-Calavi, Benin.
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  •  Received: 22 May 2021
  •  Accepted: 24 November 2021
  •  Published: 30 April 2023

Abstract

This study aims to characterize chemical groups of metabolites in extracts of Acanthospermum hispidum and Croton zambesicus, and to evaluate their anti-inflammatory activities and their immunomodulatory effect on two pro-inflammatory cytokines (TNFα and IL6). The phytochemical screening was done on the powders of both plants by staining and precipitation reactions. Anti-inflammatory activity was performed in vivo on rat paw edema induced by 2% formalin and immunomodulatory activity was performed in vitro on rat Peripheral Blood Mononuclear Cells (PBMC) stimulated by Lipopolysaccharide (LPS). The leaves of the plants contained important chemical groups such as: cachectic tannins, flavonoids, terpenes, saponosides and quinones. The ethanolic extracts of the two plants studied showed good anti-inflammatory activity by reducing the volume of the rat paw edema induced by 2% formalin and by inhibiting the production of TNFα, IL6 by PBMC of rats stimulated by LPS.

Key words: Acanthospermum hispidum, Croton zambesicus, extracts, phytochemical screening, biological activities.

Copyright © 2025 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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