Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3813

Full Length Research Paper

Effect of the route of garlic treatment on modulation of liver and spleen redox status in rats

Sonia Hamlaoui-Gasmi1*, Meherzia Mokni1, Nadia Limam1, Ferid Limam2, Ezzedine Aouani2, Mohamed AmriI1 and Lamjed Marzouki1
1Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Faculté des Sciences de Tunis, Campus Universitaire Manar II 2092 Tunis, Tunisia. 2Laboratoire des Substances Biologiquement Actives, Centre de Biotechnologie, Technopole Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunis, Tunisia.
Email: [email protected]

  •  Accepted: 12 May 2011
  •  Published: 04 August 2011


Garlic is a widely used medicinal plant exhibiting beneficial health effects such as antidiabetic, antioxidant or hypolipidemic. However several controversies persist about the beneficial or toxic effects of garlic according to its mode of administration in rat. We analyzed the ability of high dosage garlic administered per orally (p.o.) or through intraperitoneal (i.p.) route to act on liver and spleen antioxidant status in rats. In these tissue p.o. garlic is antioxidant as it decreased malondialdehyde (MDA) and H2O2 and increased catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) activities. Intraperitoneal garlic is pro-oxidant as revealed by high malondialdehyde and H2Olevels, a decrease in free iron deposition and in catalase, peroxidase and superoxide dismutase activities. In conclusion in the liver and the spleen high garlic dosage is more safe when orally administered. These effects are free iron mediated and organ specific.


Key words: Garlic, liver, spleen, antioxidant status, administration way, lipoperoxidation, free iron, hydrogen peroxide.