Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model

Akanji Olufunke Christy
  • Akanji Olufunke Christy
  • Department of Plant Science and Biotechnology, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria
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Cyril-Olutayo C. Mojisola
  • Cyril-Olutayo C. Mojisola
  • Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State Nigeria.
  • Google Scholar
Elufioye O.Taiwo
  • Elufioye O.Taiwo
  • Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State Nigeria.
  • Google Scholar
Ogunsusi Omowumi Ola
  • Ogunsusi Omowumi Ola
  • Department of Plant Science and Biotechnology, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria
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  •  Received: 06 January 2016
  •  Accepted: 31 March 2016
  •  Published: 25 June 2016

Abstract

Momordica charantia L. (Cucurbitaceae) and Mirabilis jalapa L. (Nyctaginaceae) are medicinal plants used extensively in almost all folklore remedies around the world to treat malaria. This experiment investigated the effects of M. charantia L. and M. jalapa L. on malaria in a 4-day suppressive test. Animals received 50, 100, or 200 mg/kg of methanolic extracts orally. M. charantia and M. jalapa methanolic extracts had intrinsic antimalarial properties that were dose-dependent. The result showed that M. charantia was effective in suppressing malaria at the highest dose tested (200 mg/kg) while M. jalapa gave the highest chemosuppression of parasitemia at the lowest tested dose of 50 mg/kg body weight of mice. The result also showed that the standard reference drug, Chloroquine, had its highest chemosuppression of parasitemia (100%) at 20 mg/kg when administered orally. This research affirms the uses of these plants for the treatment of malaria.

 

Key words: Antimalarial, Plasmodium berghei, M. charantia, M. jalapa.