Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3788

Review

Anti-inflammatory compounds of macro algae origin: A review

Irwandi Jaswir* and Hammed A. Monsur
Department of Biotechnology Engineering, International Islamic University Malaysia, Jalan Gombak 53100 Kuala Lumpur, Malaysia.
Email: [email protected]

  •  Accepted: 19 December 2011
  •  Published: 31 December 2011

Abstract

Inflammation, occurs frequently in living tissues, and is responsible for numerous death and precursor to some deadly diseases. This review focus on seaweed derived anti-inflammatory compounds, which have attracted interest and promising replacer of current anti-inflammatory drugs. Macro algae have both pro- and anti-inflammatory compounds, the later include sulphated polysaccharides (fucoidans) from brown seaweeds, alkaloids (Caulerpin I, II and III) from red and green seaweeds, polyunsaturated fatty acids (Docosahexaenoic acid: EDA, Eicosapentaenoic acid: EPA, Stearidonic acid: SA and Eicosatrienoic acid: ETA), carotenoids (fucoxanthin and astaxanthin), Pheophytin A and Vidalols A and B. Anti-inflammatory assays include edema, erythema, tumor necrosis factor (TNF-α), interleukin (IL 1β, 6, 8), Nitric oxide (NO), inducible Nitric oxide synthase (iNOS), Prostaglandin E (PGE 2 and 3), Cyclooxygenase (COX-2), transcription factor (NF-κB) and leukotrienes (LB 3 and 4). Although, in-vivo and in-vitro studies have been done for crude extracts and specific compounds, but some compounds have not analysed in-vitro, and investigation of their pathway need to be studied.

 

Kew words: Seaweed, anti-inflammatory, fucoidan, sulphate polysaccharide.