Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Chemical composition and biological activities of Pouteria campechiana (Kunth) Baehni

Aly M. Elsayed
  • Aly M. Elsayed
  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P. B. 11562 Cairo, Egypt.
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Nebal D. El-Tanbouly
  • Nebal D. El-Tanbouly
  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P. B. 11562 Cairo, Egypt.
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Sherifa F. Moustafa
  • Sherifa F. Moustafa
  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P. B. 11562 Cairo, Egypt.
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Rabab M. Abdou
  • Rabab M. Abdou
  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P. B. 11562 Cairo, Egypt.
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Sally A. W. El Awdan
  • Sally A. W. El Awdan
  • Pharmacology Department, National Research Center, Tahrir Street, Dokki, P. B. 12622 Cairo, Egypt.
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  •  Received: 13 December 2015
  •  Accepted: 03 March 2016
  •  Published: 25 April 2016

Abstract

The present study was conducted to evaluate the analgesic, anti-inflammatory and gastroprotective activities of ethanol, de-fatted ethanol extracts and n-hexane fractions of Pouteria campechiana (Kunth) Baehni leaves and seeds. Further chemical analysis was done to isolate and identify its bioactive compounds. The seeds ethanolic extract produced 85% inhibition of inflammation in the rat paw oedema test at the dose of 100 mg/kg after 4 h (p<0.05). On the other hand, the leaves ethanolic extract (200 mg/kg) exhibited maximum analgesic activity after 90 min (p<0.05) in the hot plate test. Both leaves and seeds ethanolic extracts showed significant decreases in gastric ulcer number and severity (p<0.05). Phytochemical investigation of P. campechiana leaves and seeds yielded six compounds: protocatechuic acid (C1), gallic acid (C2), quercetin (C3), myricetin (C4), myricetin-3-O-α-L-rhamnoside (C5) and myricetin-3-O-β-galactoside (C6). The study supports the use of P. campechiana in traditional medicine for conditions associated with inflammation, pain and peptic ulcers.

Key words: Pouteria campechiana, anti-inflammatory, analgesic, gastric ulcer, flavonoids, phenolics.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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