Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Development of a topical gel containing dried extract of Ipomoea pes-caprae brasiliensis (L.) R. Br. (Convolvulaceae)

Jerusa Adriano
  • Jerusa Adriano
  • Pharmaceutical Science, University of Itajaí Valley UNIVALI, 88302-202. Itajaí, SC, Brazil.
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Tania M. B. Bresolin
  • Tania M. B. Bresolin
  • University of Itajaí Valley (UNIVALI), Itajaí, SC, Brazil.
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Daisy J. A. Netz
  • Daisy J. A. Netz
  • University of Itajaí Valley (UNIVALI), Itajaí, SC, Brazil.
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Rilton A. de Freitas
  • Rilton A. de Freitas
  • BioPol, Chemistry Department, Federal University of Paraná, 81531-980. Curitiba, PR, Brazil.
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Angélica G. Couto*
  • Angélica G. Couto*
  • University of Itajaí Valley (UNIVALI), Itajaí, SC, Brazil. Pharmaceutical Science, University of Itajaí Valley UNIVALI, 88302-202. Itajaí, SC, Brazil
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  •  Received: 03 May 2014
  •  Accepted: 25 August 2014
  •  Published: 10 September 2014

Abstract

Gel formulations containing I. pes-caprae spray dried extract (SDE) at 0.11 and 0.18%, were developed with three types of polymers Ce = Cellosize® QP 100, Ca = Carbopol® ultrez, and Ar = Aristoflex® AVC. The pH, sensory characteristics, weight loss and the viscosity profile of gels were analyzed at times (t) t0, t90 and t180 (24 h, 90 and 180 days after their production, respectively), in ambient temperature (AT = 25 ± 2 °C), in the fridge (F = 5 ± 2 °C) and in the oven (OV = 40 ± 2 °C). Isoquercitrin assay were analyzed by High-performance liquid chromatography (HPLC), after 24h and 360 days (in AT and in the F). None of these formulations nor the spray dried extract (SDE) showed any level of cutaneous irritation in agarose overlay test. The greatest polymers were Ca and Ar in relation to their sensory characteristics and viscosity.

 

Key words: Ipomoea pes-caprae, gel, spray dried extract, stability, cytotoxicity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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