Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3804

Full Length Research Paper

Antimicrobial and antioxidant activity of the Ephedra sarcocarpa growing in Iran

Abdolhossein Rustaiyan1, Katayoun Javidnia2, Mohammad Hossein Farjam1*, Fateme Aboee-Mehrizi1 and Elham Ezzatzadeh1
1Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Email: [email protected]

  •  Accepted: 23 June 2011
  •  Published: 09 September 2011


The antimicrobial capacity of the methanolic extracts of Ephedra sarcocarpa growing in Iran is screened against Gram-positive and Gram-negative bacteria and fungi. The extract inhibited the growth of Gram-negative bacteria, being Pseudomonas aeroginosa the most susceptible one with MIC of 16 μg/mL for the extract. The antioxidant activities are evaluated using ferric reducing antioxidant power (FRAP) and 2, 2 diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. FRAP values 2.1 mmol eq quercetin/g extracts and IC50values in the DPPH assay 4.6 mg/mL. This plant had shown the high antioxidant activities. FRAP and DPPH assay results were shown good correlations with the total phenolic contents of the plants, measured by the Folin-ciocalteau assay: (r2 = 0.920 and 0.893, respectively, p < 0.0001).


Key words: Antioxidant(s), ferric reducing antioxidant power (FRAP), 2, 2 diphenyl-1-picrylhydrazyl (DPPH), total phenol, antimicrobial.