Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Influence of an aqueous extract of Coriandrum sativum leaves on the labeling of blood constituents with technetium-99m and determination of some of its physical parameters

Eric Heleno Freire Ferreira Frederico1,2, Fernanda Santos do Carmo1,3, Claudia Leite Diniz1, Marcela Paula Dantas1, Lúcia de Fátima Amorim4, Sebastião David Santos-Filho1* and Mario Bernardo-Filho1,5
1Laboratório de Radiofarmácia Experimental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. 2Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental (CLINEX), Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. 3Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. 4Departamento de Biofísica e Farmacologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil. 5Instituto Nacional do Câncer, Coordenação de Pesquisa, Rio de Janeiro, RJ, Brasil.
Email: [email protected]

  •  Accepted: 15 August 2012
  •  Published: 17 November 2012

Abstract

Coriandrum sativum (coriander) extract (leaves) (CE) is used to treat diabetes, dyspepsia, loss of appetite, seizures, insomnia, and anxiety. In the investigations about the effects of a plant extract, it is important to determine some of its physicochemical parameters. Red blood cells labeled with technetium-99m (99mTc) is used in nuclear medicine as well as in experimental models in basic research. The aim of this work was to determine some physicochemical parameters of an aqueous extract of CE and its effect on the labeling of blood constituents with 99mTc. Determinations of the absorption spectrum (AS), electric conductivity (EC), and pH have been performed using different concentrations of CE. Results showed that CE had a maximum absorbance at 480 nm. EC was inversely correlated with the concentration. We found the highest value of pH at the lower concentration of the extract (0.05 mg/ml). There was no significant (P>0.05) alteration on the labeling of the blood constituents with 99mTc. In conclusion, physicochemical parameters could be useful to characterize the CE studied. Probably, the redox properties associated with the substances of this extract could be responsible by the absence of effect on the labeling of blood constituents with 99mTc.

 

Key words: Coriandrum sativum, coriander, labeling, technetium-99m, physicochemical parameters, blood.

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