Abstract

For the fact that protein tyrosine kinases (PTKs) are important components of signal transduction pathway, they also are involved in regulating cell growth, differentiation and oncogenesis. Therefore, protein tyrosine kinases represent a potential target for cancer treatment. Drugs known as protein tyrosine kinase (PTK) inhibitors play a key role in developing therapeutic strategies for cancer therapy and plants are critical sources of natural PTK inhibitors. In the present study, we evaluated some natural anticancer molecules with PASS software in order to predict their possible targets involved in cancer. About 14 molecules (Afrormosin, Iriflogenin, Irigenin, Irisolidone, Irilone, biochanin A, Pseudobaptigenin, Pinosylvin, Galangin, Luteolin, Apigenin, Formononetin, Piceatannol and Daidzein) exhibited PTK inhibitor activity more than 0.6 theresholds. The results obtained reveal that Daidzein shows the highest PTK inhibitor activity with 0.780 score. However, Galangin has the lowest PTK inhibitory with 0.605 score. Furthermore, all of these compounds have CYP1A1 human substrate activity with score more than 0.6; therefore, Biochanin A and Daidzein with score 0.815 are the most potent CYP1A1 human substrate. In addition, all molecules had high druglikeness score and it means that they are been applied as drugs. Consequently, Biochanin A and Diadzein with 0.79 mean score are the most potent anticancer agents in our study.

Key words: Protein tyrosine kinase, plants, bioinformatics tools.