Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3693

Full Length Research Paper

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

Juliane Pereira da Silva
  • Juliane Pereira da Silva
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Jamylle Nunes de Souza Ferro
  • Jamylle Nunes de Souza Ferro
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Benisio Ferreira da Silva Filho
  • Benisio Ferreira da Silva Filho
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Luiz Antônio Ferreira da Silva
  • Luiz Antônio Ferreira da Silva
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Tayhana Priscila Medeiros Souza
  • Tayhana Priscila Medeiros Souza
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Heloisa de Carvalho Matos
  • Heloisa de Carvalho Matos
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Vinicius de Frias Carvalho
  • Vinicius de Frias Carvalho
  • Laboratory of Inflammation, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro-RJ, 21045-900, Brazil.
  • Google Scholar
Renato Santos Rodarte
  • Renato Santos Rodarte
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar
Emiliano Barreto
  • Emiliano Barreto
  • Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio-AL, 57010-020, Brazil.
  • Google Scholar


  •  Received: 02 July 2016
  •  Accepted: 01 September 2016
  •  Published: 10 September 2016

Abstract

This study evaluated the anti-allergenic properties of the aqueous extract of the stem bark from Bowdichia virgilioides (AEBv). Oral administration of AEBv inhibited the plasma protein leakage at 30 min post allergenic challenge in Swiss mice actively sensitized with ovalbumin (OVA). AEBv inhibited OVA-induced histamine release in vitro in tissues obtained from sensitized mice. AEBv-treated mice exhibited a lower influx of neutrophils and eosinophils in allergen-induced pleurisy 24 h post OVA-challenge. This treatment also reduced tumor necrosis factor (TNF)-α content in the pleural effluent. Furthermore, AEBv treatment drastically inhibited the high levels of interleukin (IL)-5 and CC chemokine eotaxin (CCL11) mRNA expression in pleural leukocytes after OVA-challenge. Preliminary toxic effects were assessed, and a qualitative phytochemical profile was performed. The extract contained condensate tannins, flavonoids, saponins, and steroids but not triterpenes and alkaloids. Oral treatment with AEBv did not induce signs of systemic toxicity or genotoxic effects. These results demonstrated that AEBv is a potent inhibitor of contributors to the allergic inflammatory response, supporting its use in folk medicine to treat allergic conditions.

Key words: Bowdichia virgilioides, allergy, inflammation, natural product.