Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

A new pterocarpan from the leaves of Abrus precatorius L.

Catherine N. Malele1, Caroline C. Lang’at-Thoruwa1, Anastasia N. Guantai2 and Sumesh C. Chhabra1*
1Chemistry Department, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya. 2Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
Email: [email protected]

  •  Received: 02 March 2015
  •  Accepted: 15 July 2015
  •  Published: 17 July 2015

Abstract

A pterocarpan, 2,3,4,8-tetramethoxy-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromene-7,9-diol (compound 1) was isolated from the dichloromethane extract of the leaves of Abrus precatorius L. The structure of the compound was elucidated by detailed spectroscopic analysis such as 1H NMR, 13C NMR, Distortionless Enhancement by Polarisation Transfer (DEPT), Heteronuclear Multiple-Quantum Correlation (HMQC) and Heteronuclear Multiple-Bond Correlation (HMBC). The crude extracts displayed brine shrimp lethality and in vitro antimalarial activity. The methanolic crude extract demonstrated a A/B ratio of 9.7 signifying that it is more toxic against Plasmodium falciparum than brine shrimp.

 

Key words:  Fabaceae, Papilionaceae, Abrus precatorius, pterocarpan, brine shrimp lethality, antiplasmodial activity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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